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SUMMARY:Plant Science Colloquium with Dr. Markus Wirtz
DTSTART;TZID=Europe/Berlin:20231208T121500
DTEND;TZID=Europe/Berlin:20231208T131500
DTSTAMP:20260914T181822Z
UID:db90b4c09f2548f898585c84b42f3f84@www.inres.uni-bonn.de
CREATED:20231207T074359Z
DESCRIPTION:N-terminal acetylation (NTA) is an ancient protein modificatio
 n conserved throughout all domains of life. N-terminally acetylated protei
 ns are present in the cytosol\, the nucleus\, the plastids\, and the plasm
 a membrane of plants. The frequency of NTA differs significantly between t
 hese subcellular compartments. While up to 80% of cytosolic and 20-30% of 
 plastidic proteins are subject to NTA\, NTA of mitochondrial proteins is r
 are. Cytosolic proteins are acetylated by five ribosome-tethered N-termina
 l acetyltransferases (NatA-NatE)\, of which NatA acetylates ~40% of the pr
 oteome in Arabidopsis thaliana. We\nrecently demonstrated that the NatA co
 mplex is a critical regulator of global proteostasis by facilitating the m
 asking of a novel N-degron. This N-degron targets many nonacetylated NatA 
 substrates for degradation by the ubiquitin-proteasome system. In this tal
 k\, we discuss the impact of NatA and its regulator HYPK on proteome plast
 icity and stress resilience.
LAST-MODIFIED:20231207T074636Z
URL:https://www.inres.uni-bonn.de/en/about/events/pflanzenwissenschaftlich
 es-kolloquium-mit-dr-markus-wirtz
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TZID:Europe/Berlin
X-LIC-LOCATION:Europe/Berlin
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DTSTART:20231029T020000
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TZOFFSETFROM:+0200
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