Ausgewählte Publikationen der AG Schaaf

2024 - 2023 - 2022 - 2021 - 2020 - 2019 - 2018 - 2017 - 2016 - 2015 - 2012 - 2011 - 2010 - 2008 - 2007 - 2006 - 2005 - 2004 - 2002 - 1999 - 1996


He X, Wang D, Jiang Y, Li M, Delgado-Baquerizo M, McLaughlin C, Marcon C, Guo L, Baer M, Moya YAT, von Wirén N, Deichmann M, Schaaf G, Piepho H-P, Yang Z, Yang J, Yim B, Smalla K, Goormachtig S, de Vries FT, Hüging H, Baer M, Sawers RJH*, Reif JC*, Hochholdinger F*, Chen X*, Yu P* (2024).
Heritable microbiome variation is correlated with source environment in locally adapted maize varieties.
Nature Plants, in press.


Siddiqui MN, Pandey K, Bhadhury SK, Sadeqi B, Schneider M, Sanchez-Garcia M, Stich B, Schaaf G, Léon J, Ballvora A (2023).
Convergently selected NPF2.12 coordinates root growth and nitrogen use efficiency in wheat and barley.
The New Phytologist, doi:

Lopez G, Ahmadi SH, Amelung W, Athmann M, Ewert F, Gaiser T, Gocke MI, Kautz T, Postma J, Rachmilevitch S, Schaaf G, Schnepf A, Stoschus A, Watt M, Yu P, Seidel SJ (2023).
Nutrient deficiency effects on root architecture and root-to-shoot ratio in arable crops.
Front. Plant Sci., doi:

Chen X-R, Poudel L, Hong Z, Johnen P, Katti S, Tripathi A, Nile AH, Green SM, Khan D, Schaaf G, Bono F, Bankaitis VA, Igumenova TI (2023).
Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity.
J Biol Chem, doi:

Liu G, Riemer E, Schneider R, Cabuzu D, Bonny O, Wagner CA, Qiu D, Saiardi A,  Strauss A,  Lahaye T, Schaaf G, Knoll T, Jessen JP, Jessen HJ (2023).
The phytase RipBL1 enables the assignment of a specific inositol phosphate isomer as a structural component of human kidney stones.
RSC Chem. Biol., doi:

He X, Wang D, Jiang Y, Li M, Delgado-Baquerizo M, McLaughlin C, Marcon C, Guo L, Baer M, Moya YAT, von Wirén N, Deichmann M, Schaaf G, Piepho HP, Yang Z, Yang J, Yim B, Smalla K, Goormachtig S, de Vries FT, Hüging H, Sawers RJH, Reif JC, Hochholdinger F, Chen X, Yu P (2023).
Heritable maize microbiomes contribute to local adaptation and host stress resilience.
bioRxiv, doi:


Macabuhay A, Arsova B, Watt M, Nagel KA, Lenz H, Putz A, Adels S, Müller-Linow M, Kelm J, Johnson AAT, Walker R, Schaaf G, Roessner U (2022).
Plant Growth Promotion and Heat Stress Amelioration in Arabidopsis Inoculated with Paraburkholderia phytofirmans PsJN Rhizobacteria Quantified with the GrowScreen-Agar II Phenotyping Platform.
Plants 2022, 11(21), 2927; doi:

Chen X-R, Poudel L, Hong Z, Johnen P, Katti SS, Tripathi A, Nile AH, Green SM, Schaaf G, Bono F, Bankaitis VA, Igumenova TI (2022).
Mechanisms by Which Small Molecule Inhibitors Arrest Sec14 Phosphatidylinositol Transfer Protein Activity.
bioRxiv, doi:

Liu C, Mentzelopoulou A, Deli A, Papagavriil F, Ramachandran P, Perraki A, Claus L, Barg S, Dörmann P, Jaillais Y, Johnen P, Russinova E, Gizeli E, Schaaf G, Moschou PN (2022).
Phase Separation of a Nodulin Sec14-like protein Maintains Auxin Efflux Carrier Polarity at Arabidopsis Plasma Membranes.
bioRxiv, doi:

Parvin Laha N, Giehl RFH, Riemer E, Qiu D, Pullagurla NJ, Schneider R, Walia Dhir Y, Yadav R, Mihiret YE, Gaugler P, Gaugler V, Mao H, Zheng N, von Wirén N, Adolfo Saiardi, Bhattacharjee S, Jessen HJ, Laha D, Schaaf G (2022).
INOSITOL (1,3,4) TRIPHOSPHATE 5/6 KINASE1-dependent inositol polyphosphates regulate auxin responses in Arabidopsis.
Plant Physiology, doi:

Riemer E, Pullagurla NJ, Yadav R, Rana P, Jessen HJ, Kamleitner M, Schaaf G, Laha D (2022).
Regulation of plant biotic interactions and abiotic stress responses by inositol polyphosphates.
Front. Plant Sci., doi:

Gaugler P, Schneider R, Liu G, Qiu D, Weber J, Schmid J, Jork N, Häner M, Ritter K, Fernández Rebollo N, Giehl RFH, Trung MN, Yadav R, Fiedler D, Gaugler V, Jessen HJ, Schaaf G, Laha D (2022).
Arabidopsis PFA-DSP-type phosphohydrolases target specific inositol pyrophosphate messengers.
bioRxiv: 2022.2003.2001.482514, doi:

Mau L, Junker S, Bochmann H, Mihiret YE, Kelm JM, Schrey SD,  Roessner U, Schaaf G, Watt M, Kant J, Arsova B (2022).
Root Growth and Architecture of Wheat and Brachypodium Vary in Response to Algal Fertilizer in Soil and Solution.
Agronomy 2022, 12, 285, doi:

Gulabani H, Goswami K, Walia Y, Roy A, Noor JJ, Ingole KD, Kasera M, Laha D, Giehl RFH, Schaaf G, Bhattacharjee S (2022).
Arabidopsis inositol polyphosphate kinases IPK1 and ITPK1 modulate crosstalk between SA-dependent immunity and phosphate-starvation responses.
Plant Cell Reports, 1-17. doi: 10.1007/s00299-021-02812-3 


Haas TM, Mundinger S, Qiu D, Jork N, Ritter K, Dürr-Mayer T, Ripp A, Saiardi A, Schaaf G, Jessen HJ (2021).
Stable isotope phosphate labelling of diverse metabolites is enabled by a family of 18O‐phosphoramidites.
Angew Chem Int Ed Engl, doi:

Riemer E, Qiu D, Laha D, Harmel RK, Gaugler P, Gaugler V, Frei M, Hajirezaei MR, Laha NP, Krusenbaum L, Schneider R, Saiardi A, Fiedler D, Jessen HJ, Schaaf G, Giehl RFH (2021).
ITPK1 is an InsP6/ADP phosphotransferase that controls phosphate signaling in Arabidopsis.
Molecular Plant 14, 1864-1880.

Walia Y, Kasera M, Ingole KD, Peddiraju S, Roy A, Laha D, Schaaf G, Bhattacharjee S (2021).
Arabidopsis inositol polyphosphate kinases regulate COP9 signalosome deneddylase functions in phosphate-homeostasis.
bioRxiv, doi:

Laha D, Kamleitner M, Johnen P, Schaaf G (2021).
Analyses of Inositol Phosphates and Phosphoinositides by Strong Anion Exchange (SAX)-HPLC.
Plant Lipids, 365-378.

Gulabani H, Goswami K, Walia Y, Noor JJ, Ingole KD, Roy A, Laha D, Schaaf G, Bhattacharjee S (2021).
Arabidopsis inositol polyphosphate kinases IPK1 and ITPK1 modulate crosstalks between SA-dependent immunity and phosphate-starvation responses.
bioRxiv, doi:

Yu P, He X, Baer M, Beirinckx S, Tian T, Moya YAT, Zhang Y, Deichmann M, Frey FP, Bresgen V, Li C, Razavi BS, Schaaf G, von Wirén N, Su Z, Bucher M, Tsuda K, Goormachtig S, Chen X, Hochholdinger F (2021).
Plant flavones enrich rhizosphere Oxalobacteraceae to improve maize performance under nitrogen deprivation.
Nature Plants 7, 481–499.

Seidel SJ, Gaiser T, Ahrends HE, Hüging H, Siebert S, Bauke SL, Gocke MI, Koch M, Schweitzer K, Schaaf G, Ewert F (2021).
Crop response to P fertilizer omission under a changing climate - Experimental and modeling results over 115 years of a long-term fertilizer experiment.
Field Crops Research 268, 108174.


Qiu D, Wilson MS, Eisenbeis VB, Harmel RK, Riemer E, Haas TM, Wittwer C, Jork N, Gu C, Shears SB, Schaaf G,  Kammerer B, Fiedler D, Saiardi A, Jessen HJ (2020).
Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry.
Nature Communications 11, 6035.

Yi J, Krusenbaum L, Unger P, Hüging H, Seidel S, Schaaf G, Gall J (2020).
Deep learning for non-invasive diagnosis of nutrient deficiencies in sugar beet using RGB images. Sensors 20(20), 5893; doi:10.3390/s20205893.

Gaugler P, Gaugler V, Kamleitner M, Schaaf G (2020).
Extraction and Quantification of Soluble, Radiolabeled Inositol Polyphosphates from Different Plant Species using SAX-HPLC.
J Vis Exp (160), e61495, doi:10.3791/61495.


Laha D, Parvin N, Hofer A, Giehl RFH, Fernandez-Rebollo N, von Wirén N, Saiardi A, Jessen HJ, Schaaf G (2019).
Arabidopsis ITPK1 and ITPK2 Have an Evolutionarily Conserved Phytic Acid Kinase Activity.
ACS Chem. Biol.; doi: 10.1021/acschembio.9b00423. [Epub ahead of print]

Zhu J, Lau K, Puschmann R, Harmel RK, Zhang Y, Pries V, Gaugler P, Broger L, Dutta AK, Jessen HJ, Schaaf G, Fernie AR, Hothorn LA, Fiedler D, Hothorn M (2019).
Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis.
eLife;8:e43582 doi: 10.7554/eLife.43582


Pries V, Nöcker C, Khan D, Johnen P, Hong Z, Tripathi A, Keller AL, Fitz M, Perruccio F, Filipuzzi I, Thavam S, Aust T, Riedl R, Ziegler S, Bono F, Schaaf G, Bankaitis VA, Waldmann H, Hoepfner D (2018).
Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.
Cell Chemical Biology 25, 1–12 doi: 10.1016/j.chembiol.2017.12.007.


Zhang Q, van Wijk R, Shahbaz M, Roels W, van Schooten B, Vermeer J,  Zarza X, Guardia A, Scuffi D, García-Mata C, Laha D, Williams P, Willems L, Ligterink W, Hoffmann-Benning S, Gillaspy G, Schaaf G, Haring M, Laxalt A, Munnik T (2017).
Arabidopsis Phospholipase C3 is Involved in Lateral Root Initiation and ABA Responses in Seed Germination and Stomatal Closure.
Plant and Cell Physiology, pcx194.

Blüher D, Laha D, Thieme S, Hofer A, Eschen-Lippold L, Masch A, Balcke G, Pavlovic I, Nagel O, Schonsky A, Hinkelmann R, Wörner J, Parvin N, Greiner R, Weber S, Tissier A, Schutkowski M, Lee J, Jessen H, Schaaf G, Bonas U* (2017).
A 1-phytase type III effector interferes with plant hormone signaling.
Nature communications 8, 2159.

de Campos MK, Schaaf G (2017).
The regulation of cell polarity by lipid transfer proteins of the SEC14 family.
Curr Opin Plant Biol 40, 158-168


Laha D, Parvin N, Dynowski M, Johnen P, Mao H, Bitters ST, Zheng N, Schaaf G (2016). 
Inositol polyphosphate binding specificity of the jasmonate receptor complex.
Plant Physiol 171, 2364-70


Pavlovic I, Thakor DT, Bigler L, Wilson MSC, Laha D, Schaaf G, Saiardi A, Jessen HJ (2015).
Pro-Metabolites of 5-diphospho-myo-inositol pentakisphosphate.
Angew Chem Int Ed 54, 9622-6

Laha D, Johnen P, Azevedo C, Dynowski M, Weiß M, Capolicchio S, Mao H, Iven T, Steenbergen M, Freyer M, Gaugler P, de Campos MKF, Zheng N, Feussner I, Jessen HJ, Van Wees SC, Saiardi A, and Schaaf G (2015).
VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP8 and Jasmonate-Dependent Defenses in Arabidopsis.
Plant Cell 27, 1082-97

Ghosh R, de Campos MK, Huang J, Huh SK, Orlowski A, Yang Y, Tripathi A, Nile A, Lee HC, Dynowski M, Schäfer H, Róg T, Lete MG, Ahyayauch H, Alonso A, Vattulainen I, Igumenova TI, Schaaf G, Bankaitis VA (2015).
Sec14-Nodulin Proteins and the Patterning of Phosphoinositide Landmarks for Developmental Control of Membrane Morphogenesis.
Mol Biol Cell 26, 1764-81


Bankaitis VA, Ile KE, Nile AH, Ren J, Ghosh R, Schaaf G (2012).
Thoughts on Sec14-like nanoreactors and phosphoinositide signaling.
Adv Biol Regul 52, 115-21


Winklbauer EM, de Campos MKF, Dynowski D, and Schaaf G (2011).
A blueprint for functional engineering: Single point mutations reconstitute phosphatidylinositol presentation in a pseudo-Sec14 protein.
Commun Integr Biol 4, 674

Ren J, Schaaf G, Bankaitis VA, Ortlund EA, and Pathak MC (2011).
Crystallization and Preliminary X-ray Diffraction Analysis of Sfh3, a Member of the Sec14-protein Superfamily.
Acta Cryst F 67, 1239-1243

Schaaf G, Dynowski D, Mousley CJ, Shah SD, Yuan P, Winklbauer EM, Kaphan Freitas de Campos M, Trettin K, Quinones MC, Smirnova T, Yanagisawa LL, Ortlund EA, and Bankaitis VA (2011).
Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution.
Mol Biol Cell 22, 892-905


Mousley CJ, Trettin KD, Tyeryar K, Ile KE, Schaaf G, Bankaitis VA (2010).
Sphingolipid metabolism in trans-Golgi/endosomal membranes and the regulation of intracellular homeostatic processes in eukaryotic cells.
Adv Enzyme Regul 50, 339-48

Bankaitis VA, Mousley CJ, Schaaf G (2010).
The Sec14 superfamily and mechanisms for cross-talk between lipid metabolism and lipid signaling.
Trends Biochem Sci 35, 150-60


Mousley CJ, Tyeryar KR, Ile KE, Schaaf G, Brost RL, Boone C, Guan X, Wenk MR, Bankaitis VA (2008).
Coordinate defects in Sec14 and Tlg2-dependent trans-Golgi and endosome dynamics derange ceramide homeostasis and compromise the unfolded protein response.
Mol Biol Cell 19, 4785-803

Dynowski M, Schaaf G, Loque D, Moran O, Ludewig U (2008).
Plant plasma membrane water channels conduct the signaling molecule H2O2.
Biochem J 414, 53-61

Schaaf G, Ortlund EA, Tyeryar KR, Mousley CJ, Ile KE, Garrett TA, Ren J, Woolls MJ, Raetz CRH, Redinbo MR, Bankaitis VA (2008).
Functional Anatomy of Phospholipid Binding and Regulation of Phosphoinositide Homeostasis by Proteins of the Sec14 Superfamily.
Mol Cell 29, 191-206 


Smirnova TI, , Chadwick TG, Voinov MA, Poluektov O, van Tol J, Ozarowski A, Schaaf G, Ryan MM, and Bankaitis VA (2007).
Local Polarity and Hydrogen Bonding inside the Sec14p Phospholipid-binding Cavity: High-Field Multifrequency EPR Studies.
Biophysical J 92, 3686-95

Meda AR, Scheuermann E, Prechsl U, Erenoglu B, Schaaf G, Hayen H, Weber G, and von Wirén N (2007).
Iron Acquisition by Phytosiderophores Contributes to Cadmium Tolerance.
Plant Physiol 143, 1761-73


Smirnova TI, Chadwick TG, MacArthur R, Poluektov O, Song L, Ryan MM, Schaaf G, and Bankaitis VA (2006).
The chemistry of phospholipid binding by the Saccharomyces cerevisiae phosphatidylinositol transfer protein Sec14p as determined by EPR spectroscopy.
J Biol Chem 281, 34897-908

Schaaf G, Betts L, Garrett TA, Raetz CRH and Bankaitis VA (2006).
Crystallization and preliminary X-ray diffraction analysis of Sfh1p: A member of the Saccharomyces cerevisea Sec14p-like phosphatidylinositol transfer protein family.
Acta Cryst F 62, 1156-60

Ile KE, Schaaf G, and Bankaitis VA (2006).
Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid signaling.
Nature Chem Biol 2, 576-583

Schaaf G, Honsbein A, Meda AR, Kirchner S, Wipf D and von Wirén N (2006).
AtIREG2 Encodes a Tonoplast Transport Protein Involved in Fe-Dependent Ni Detoxification in Arabidopsis thaliana Roots.
J Biol Chem 281, 25532-25540 

Takano J, Wada M, Ludewig U, Schaaf G, von Wirén N, Fujiwara T (2006).
The Arabidopsis Major Intrinsic Protein NIP5;1 Is Essential for Efficient Boron Uptake and Plant Development under Boron Limitation.
Plant Cell 18, 1498 - 1509

Mayer M, Schaaf G, Mouro I, Lopez C, Colin Y, Neumann P, Cartron JP, Ludewig U (2006).
Different Transport Mechanisms in Plant and Human AMT/Rh-type Ammonium Transporters.
J Gen Physiol 127, 133-44

Phillips SE, Vincent P, Rizzieri KE, Schaaf G, Gaucher EA, Bankaitis VA (2006).
The diverse biological functions of phosphatidylinositol transfer proteins in eukaryotes.
Crit Rev Biochem Mol Biol 41, 21-49


Schaaf G, Schikora A, Häberle J, Vert G, Ludewig U, Briat JF, Curie C and von Wirén N (2005).
A putative function of the Arabidopsis Fe-phytosiderophore transporter homolog AtYSL2 in Fe and Zn homeostasis.
Plant Cell Physiol 46, 762-774 


Römheld V and Schaaf G (2004).
Iron transport in plants: Future research in view of a plant nutritionist and a molecular biologist.
Soil Sci Plant Nutr 50, 1003 - 1012 

Schaaf G, Erenoglu BE and von Wirén N (2004).
Physiological and biochemical characterization of metal-phytosiderophore transport in graminaceous species.
Soil Sci Plant Nutr 50, 955 - 964

Schaaf G, Ludewig U, Erenoglu BE, Mori S, Kitahara T, von Wirén N (2004).
ZmYS1 functions as a proton-coupled symporter for phytosiderophore- and nicotianamine-chelated metals.
J Biol Chem  279, 9091-9096


Schaaf G, Catoni E, Fitz M, Schwacke R, Schneider A, von Wirén N, Frommer WB (2002).
A putative role for the vacuolar calcium/manganese proton antiporter AtCAX2 in heavy metal detoxification.
Plant Biology 4, 612-618




Schaaf G (2004).
Molecular and Biochemical Characterization of Plant Transporters Involved in the Cellular Homeostasis of Mn and Fe (Dissertation).
Der Andere Verlag, Osnabrück, Germany ISBN 3899592085

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